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KMID : 0371320060710030183
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Journal of the Korean Surgical Society
2006 Volume.71 No. 3 p.183 ~ p.188
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Expressions of Galectin-3 and HBME-1 in Nodular Lesions of the Thyroid
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최정욱/Choi JW
김범규/차성재/이태진/박성준/박성일/Kim BG/Cha SJ/Lee TJ/Park SJ/Park SI
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Abstract
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Purpose: Galectin-3 and HBME-1 have been recognized as useful markers for the diagnosis of the thyroid lesions. In this study, we investigated whether they have a diagnostic value for nodular lesions of the thyroid.
Methods: We investigated the galectin-3 and HBME-1 expressions in 14 nodular hyperplasias, 30 papillary carcinomas, 17 follicular adenomas and 8 follicular carcinomas with using immunochemistry.
Results: Galectin-3 was positive in 96.7% of the papillary carcinomas and this incidence was significantly higher (P=0.0001) than that of nodular hyperplasia, 7.1%. However, the galectin-3 expressions of follicular adenoma and follicular carcinoma were not significantly different. HBME-1 was positive in 50.0% of the follicular carcinomas and this incidence was significantly higher (P=0.0001) than that of follicular adenoma.
Conclusion: Galectin-3 and HBME-1 may be useful markers to diagnose papillary carcinoma. Although HBME-1 contributes to differential diagnosis of follicular adenoma and follicular carcinoma, further study is required. (J Korean Surg Soc 2006;71:183-188)
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